2426 Role of immunoregulatory cytokines TGF-β, IL-4, IL-10, in the in vitro production of TNF and NO by retinal resident cells

m We have su~ested a role for nitric oxide as a mediir of the autoimmune dcattuaion of tbe retina in our rat model of EAU. ln orevious immunohktochanical studies we detected the iNOS enzyme only dkng and at the site of active disease, c&xalising’tith activated ED1 positive macrophages intiltrating the retina. The ah of this study was to detect iNOS mRNA and investigate the eqreasion of intlammatory cytokines, knovm to be important In the hlducti0r1 of iNos in vifro, in diseased eyes throughout progression of EAU.